Briefing: New method reveals hidden stereochemical forms of oxidation in antibody drugs
Strategic angle: A breakthrough technique uncovers previously undetected oxidation forms in monoclonal antibodies, impacting their efficacy.
Monoclonal antibodies are essential biologic medicines used in the treatment of various conditions, including cancer and autoimmune diseases. Their effectiveness is closely tied to their structural integrity.
Oxidation can occur during the manufacturing process, as well as during storage and transport, potentially compromising the quality of these drugs. Understanding these changes is critical for maintaining drug efficacy.
The newly introduced method enhances the detection of these oxidation forms, providing insights into antibody stability and potentially guiding improvements in manufacturing practices.